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Antitumor agent-67

CAT: 0804-HY-146114Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146114Size:1 Each
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Description
Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity[1].
CAS Number
2820146-10-7
UNSPSC
12352005
Target
Microtubule/Tubulin; Quinone Reductase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-67.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC=C(N(C)C(CC(C2=C(C)C(C(C)=C(C)C2=O)=O)(C)C)=O)C=C1)O[C@H]3[C@]4([H])[C@@](C(OC4)=O)([H])[C@H](C5=CC(OC)=C(OC)C(OC)=C5)C6=C3C=C7OCOC7=C6
Molecular Formula
C45H47NO13
Molecular Weight
809.85
References & Citations
[1]Qu Y, et al. Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents. Bioorg Med Chem. 2020;28 (24) :115821.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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