Antitumor agent-57

• Description:

  Antitumor agent-57 (Compound 3o) is an NQO1-directed antitumor agent. Antitumor agent-57 inhibits tumor cell growth, triggers ROS generation and induces cell apoptosis[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-57.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC2=C(C(C(C3=CC=CC=C32)=O)=O)C(C4=CC=C(OC)C(O)=C4)C1

• Molecular Formula:

  C20H15NO5

• Molecular Weight:

  349.34

• References & Citations:

  [1]Wu LQ, et al. Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6 (1H) -triones as NQO1-directed antitumor agents. Eur J Med Chem. 2020 Jul 15;198:112396.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2432823-48-6]