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Antitumor agent-49

CAT: 0804-HY-145908Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145908Size:1 Each
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Description
Antitumor agent-49 (Compound 10) is a Harmine derivative-furoxan hybrids containing NO donor, with antitumor activities. Antitumor agent-49 shows cytotoxic activity against HepG2 cells with an IC50 of 1.79 µM. Antitumor agent-49 produces high levels of NO in vitro[1].
CAS Number
2763914-21-0
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-49.html
Solubility
10 mM in DMSO
Smiles
CC1=[N+](C=CC2=C1N(C3=C2C=CC(OCC(OCCCCOC4=NO[N+]([O-])=C4S(=O)(C5=CC=CC=C5)=O)=O)=C3)CCCC6=CC=CC=C6)CC7=CC=CC=C7.[Br-]
Molecular Formula
C42H41BrN4O8S
Molecular Weight
841.77
References & Citations
[1]Zhezhe Li, et al. Synthesis of harmine-nitric oxide donor derivatives as potential antitumor agents. Bioorg Med Chem Lett. 2022 Mar 24;65:128698.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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