BMS-986169

CAT: 0804-HY-119886Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-119886Size:1 Each
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Description
BMS-986169 is an inhibitor of the glutamate N-methyl-D-aspartate 2B receptor (GluN2B) . BMS-986169 has a high binding affinity for the allosteric regulatory site of the GluN2B subunit, with a Ki value of 4.03-6.3 nM. BMS-986169 can inhibit the function of GluN2B receptors in Xenopus oocytes, with an IC50 value of 24.1 nM. BMS-986169 can also inhibit the activity of the hERG channel, with an IC50 value of 28.4 μM. BMS-986169 can be used in research on treatment-resistant depression[1].
CAS Number
[1801151-08-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bms-986169.html
Smiles
O=C1N(CC[C@H]1N2C[C@H]([C@@H](CC2)C3=CC=C(C=C3)O)F)CC4=CC=C(C=C4)C
Molecular Formula
C23H27FN2O2
Molecular Weight
382.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Bristow LJ, et al. Preclinical Characterization of (R) -3- ((3S,4S) -3-fluoro-4- (4-hydroxyphenyl) piperidin-1-yl) -1- (4-methylbenzyl) pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder. J Pharmacol Exp Ther. 2017 Dec;363 (3) :377-393.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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