BMS-986142

CAT: 0804-HY-101856-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101856-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
BMS-986142 is a potent and highly selective reversible inhibitor of Bruton's tyrosine kinase (BTK) with an IC50 of 0.5 nM.
CAS Number
[1643368-58-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BMS-986142.html
Purity
99.38
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C(F)=CC=C2)N(C)C(N1C3=C([C@]([C@]4=C(F)C=C(C(N)=O)C5=C4C6=C(C[C@@H](C(C)(C)O)CC6)N5)=CC=C3)C)=O
Molecular Formula
C32H30F2N4O4
Molecular Weight
572.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Watterson SH, et al. Discovery of 6-Fluoro-5- (R) - (3- (S) - (8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3 (4H) -yl) -2-methylphenyl) -2- (S) - (2-hydroxypropan-2-yl) -2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142) : A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. J Med Chem. 2016 Oct 13;59 (19) :9173-9200.|[2]Kathleen M. Gillooly, et al. Bruton'styrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care. PLoS One. 2017; 12 (7) : e0181782.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Related Products

CatalogName
HY-145373BMS-986143
HY-118416-01BMS-986124
HY-120645-01BMS-986122
HY-139204-01BMS-986242
HY-131905S-01BMS-986144
HY-150790-01BMS-986141
HY-149663-01BMS-986172
HY-131968-01BMS-986202
HY-124995BMS-986126
HY-19837-01BMS-986120

Alternative Products

CatalogName
BA8836-5BMS-986142
A19993-100BMS-986142 100mg
A19993-200BMS-986142 200mg
A19993-10BMS-986142 10mg
A19993-50BMS-986142 50mg
A19993-1BMS-986142 1mg
A19993-500BMS-986142 500mg
A19993-5BMS-986142 5mg
A19993-25BMS-986142 25mg
A19993-10mM-DBMS-986142 10mM * 1mL in DMSO

Popular Products