BMS-986189

• UNSPSC Description:

  BMS-986189 is a macrocyclic peptide inhibitor of PD-L1 (IC50: 1.03 nM), and can be used for cancer research[1].

• Target Antigen:

  PD-1/PD-L1

• Type:

  Peptides

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bms-986189.html

• Purity:

  95.46

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  OC(CN1C2=CC=CC=C2C(C[C@H]3C(N([C@H](C(N([C@H](C(N[C@H](C(N[C@@H](CSCC(N[C@H](C(N([C@H](C(N[C@H](C(N4[C@](CCC4)([H])C(N[C@H](C(N[C@H](C(N5[C@](C[C@H](C5)O)([H])C(N[C@H](C(N[C@H](C(N3)=O)CCN)=O)CC6=CNC7=CC=CC=C67)=O)=O)CC(C)C)=O)CN)=O)=O)CC(N)=O)=O)C)C)=O)CC8=CC=C(C=C8)O)=O)C(NCC(N)=O)=O)=O)CC(C)C)=O)CCCC)C)=O)CCCC)C)=O)=C1)=O

• Molecular Weight:

  1887.21

• References & Citations:

  [1]Yang J, et al. Utilization of macrocyclic peptides to target protein-protein interactions in cancer. Front Oncol. 2022 Nov 17;12:992171.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  Phase 1

• CAS Number:

  1629665-96-8