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SOS1-IN-5

CAT: 0804-HY-145048Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145048Size:1 Each
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Description
SOS1-IN-5 is a potent inhibitor of SOS1. SOS1-IN-5 is a pyrimidobicyclic derivative. SOS1-IN-5 blocks the activation of KRAS by interfering with RAS-SOS1 interaction, and achieves the purpose of broad-spectrum inhibition of KRAS activity. SOS1-IN-5 has the potential for the research of cancer diseases (extracted from patent WO2021203768A1, compound 4) [1].
CAS Number
2716956-47-5
UNSPSC
12352005
Target
Ras; SOS1
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-in-5.html
Solubility
10 mM in DMSO
Smiles
C[C@H](C1=CC(C(F)(F)F)=CC(N)=C1)NC2=NC(C)=NC3=C2C=C(OCCOCCOCCOCCO4)C4=C3
Molecular Formula
C26H31F3N4O5
Molecular Weight
536.54
References & Citations
[1]Xin Li, et al. Pyrimidobicyclic derivatives, their preparation method and their application in medicine. Patent WO2021203768A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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