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SOS1-IN-22

CAT: 0804-HY-175560Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175560Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SOS1-IN-22 is a son of sevenless homolog 1 (SOS1) inhibitor. SOS1-IN-22 can inhibit KRAS-G12C/SOS1 complex formation with an IC50 value of 40.28 nM. SOS1-IN-22 can reduce phosphorylation ERK levels. SOS1-IN-22 can be used for the research of cancer, such as pancreatic carcinoma and appendiceal carcinoma[1].
CAS Number
3092445-74-1
UNSPSC
12352005
Target
PERK; SOS1
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1C(C)(C)C2=NC(C)=NC(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=C2CN1C4CCOCC4
Molecular Formula
C24H29F3N4O2
Molecular Weight
462.51
References & Citations
[1]Chen X, et al. Development and biological evaluation of novel SOS1 inhibitors featuring 5,8-dihydropyrido[4,3-d]pyrimidin-7 (6H) -one scaffold. Bioorg Med Chem Lett. 2025 Dec 1;128:130344.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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