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SOS1-IN-20

CAT: 0931-T211427-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211427-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Raf, Ras, Potassium Channel
Related Pathways
MAPK, Membrane transporter/Ion channel
Bioactivity
SOS1-IN-20 (Compound 12f) is an orally active inhibitor of SOS1, exhibiting an IC50 of 5.11 nM against KRASG12C::SOS1. It prevents KRAS activation and its downstream signaling by disrupting the KRAS-SOS1 interaction. In PC-9 cells, it shows an IC50 of 253 nM for p-ERK, while its IC50 for the hERG channel is 16.71 μM. SOS1-IN-20 also inhibits tumor cell proliferation, displaying antitumor activity.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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