SOS1-IN-19

CAT: 0804-HY-176170Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-176170Size:1 Each
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Description
SOS1-IN-19 (Compound 10i) is a potent inhibitor of SOS1 (Son of Sevenless 1) with an IC50 value of 165.2 nM. SOS1-IN-19 blocks KRAS activation by preventing GDP/GTP exchange in KRAS signaling pathway. SOS1-IN-19 is promising for research of KRAS-driven cancers (e.g., NSCLC and colorectal cancer) [1].
UNSPSC
12352005
Target
SOS1
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Smiles
COC1=C(OC)C=C2C(N=C(N3CC(N(C)C)C3)N=C2N[C@H](C)C4=CC(N)=CC(C(F)(F)F)=C4)=C1
Molecular Formula
C24H29F3N6O2
Molecular Weight
490.52
References & Citations
[1]Chen Y, et al. Design and structural optimization of novel SOS1 inhibitors in KRAS-driven cancers. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130282.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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