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SOS1 Ligand intermediate-5

CAT: 0804-HY-161655Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161655Size:1 Each
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Description
SOS1 Ligand intermediate-5 is the ligand for son of sevenless 1 (SOS1). SOS1 Ligand intermediate-5 is utilized for synthesis of PROTAC SOS1 degrader-10.
CAS Number
3043923-70-9
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; SOS1
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sos1-ligand-intermediate-5.html
Solubility
10 mM in DMSO
Smiles
NC1=CC(C(F)(F)F)=CC([C@@H](C)NC2=C3C(N(C)C(C([C@H]4CC[C@H](C(O)=O)CC4)=C3)=O)=NC=N2)=C1
Molecular Formula
C24H26F3N5O3
Molecular Weight
489.49
References & Citations
[1]Wang, K, et al. “Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor.” Bioorganic & medicinal chemistry letters vol. 107 (2024) : 129780.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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