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Bcl-2-IN-6

CAT: 0804-HY-144791Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144791Size:1 Each
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Description
Bcl-2-IN-6 (compound 10) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC50 values of 20.91, 22.30, 42.29, and 48.00 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively[1].
CAS Number
3027734-50-2
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(CC)=C1)CSC(N2C3=CC=C(S(=O)(N)=O)C=C3)=NC4=C(C=CC=C4OC)C2=O
Molecular Formula
C25H24N4O5S2
Molecular Weight
524.61
References & Citations
[1]Alqahtani AS, et al. Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :86-99.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 7

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