Bcl-2-IN-6

• Description :

  Bcl-2-IN-6 (compound 10) is a potent Bcl-2 (B-cell lymphoma-2) inhibitor. Bcl-2-IN-7 down-regulates the expression of Bcl-2, and increases the expression of p53, Bax, and caspase-7 mRNA. Bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. Bcl-2-IN-7 shows good anticancer activity, with IC50 values of 20.91, 22.30, 42.29, and 48.00 μM against MCF-7, LoVo, HepG2, and A549 cell lines, respectively[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bcl-2-in-6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=CC=CC(CC)=C1)CSC(N2C3=CC=C(S(=O)(N)=O)C=C3)=NC4=C(C=CC=C4OC)C2=O

• Molecular Formula :

  C25H24N4O5S2

• Molecular Weight :

  524.61

• References & Citations :

  [1]Alqahtani AS, et al. Novel sulphonamide-bearing methoxyquinazolinone derivatives as anticancer and apoptosis inducers: synthesis, biological evaluation and in silico studies. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :86-99.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Bax; Bcl-2; Caspase 7

• CAS Number :

  [3027734-50-2]