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Bcl-2-IN-23

CAT: 0804-HY-176219Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176219Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl-2-IN-23 (compound 5) is a selective inhibitor targeting Bcl-2. The IC50 of Bcl-2-IN-23 in HTB-140, HeLa and SW620 cells is 25.7-33.7 μM. Bcl-2-IN-23 can non-covalently competitively bind to Bcl-2 protein, significantly reduce its expression, and induce late apoptosis and necroptosis of cancer cells. Bcl-2-IN-23 enhances the sensitivity of cancer cells to apoptosis and reduces the release of IL-6 inflammatory factors by disrupting the Bcl-2-mediated mitochondrial apoptosis inhibition pathway. Bcl-2-IN-23 can be used for anti-apoptosis research of malignant tumors such as melanoma, cervical cancer, and colorectal cancer[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Necroptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=CC(C2=CC=C(NC3=NN=NN3CCC4=CC=CC=C4)C(OC)=C2)=CC=C1NC5=NN=NN5CCC6=CC=CC=C6
Molecular Formula
C32H32N10O2
Molecular Weight
588.66
References & Citations
[1]Olejarz W, et al. Design and in vitro evaluation of novel tetrazole derivatives of dianisidine as anticancer agents targeting Bcl-2 apoptosis regulator. Sci Rep. 2025 May 21;15 (1) :17634.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2

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