Bcl-2-IN-6

• Target:

  Others|||Apoptosis|||Bcl-2 Family|||Caspase|||MDM-2/p53

• Related Pathways:

  Proteases/Proteasome|||Apoptosis|||Others

• Bioactivity:

  Bcl-2-IN-6 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2) that downregulates Bcl-2 expression and increases the expression of p53, Bax, and caspase-7 mRNA. bcl-2-IN-7 induces cell cycle arrest and apoptosis in breast cancer MCF-7 cells. bcl-2-IN-7 acts on MCF-7 cells (Bcl2-IN-7 showed good antitumor effects on MCF-7 cells (IC50: 20.91 ?M), LoVo cells (IC50: 22.30 ?M), HepG2 cells (IC50: 42.29 ?M) and A549 cells (IC50: 48.00 ?M) .

• Molecular Formula:

  C25H24N4O5S2

• Molecular Weight:

  524.61

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C