BCL-6 Antibody

• Description:

  The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

• Specifications:

  Western blot: 1:100-1:250

• UniProt:

  P41182

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  A portion of amino acids 676-704 from the human protein was used as the immunogen for this BCL-6 antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG1 k

• Clone:

  305CT16.3.3

• Applications:

  WB, ELISA

• Purity:

  Purified

• Format:

  Purified

• Buffer:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Reconstitution:

  Aliquot the BCL-6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This BCL-6 antibody is available for research use only.

• Storage Conditions:

  Aliquot the BCL-6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  In 1X PBS, pH 7.4, with 0.09% sodium azide

• Applications Notes:

  Titration of the BCL-6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

• CAS Number:

  9007-83-4

• Image Legend:

  BCL-6 antibody western blot analysis in NCI-H292 lysate. Predicted molecular weight: 78~100 kDa.