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FXIa-IN-8

CAT:
804-HY-144658
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
FXIa-IN-8 - image 1

FXIa-IN-8

  • CAS Number: 2744293-04-5
  • UNSPSC Description: FXIa-IN-8 is a potent and selective FXIa inhibitor with an IC50 of 14.2 nM. FXIa-IN-8 shows antithrombotic activity without increasing the bleeding risk and obvious toxicitysup>[1].
  • Target Antigen: Factor Xa
  • Type: Reference compound
  • Related Pathways: Metabolic Enzyme/Protease
  • Applications: Neuroscience-Neuromodulation
  • Field of Research: Cardiovascular Disease
  • Assay Protocol: https://www.medchemexpress.com/fxia-in-8.html
  • Solubility: 10 mM in DMSO
  • Smiles: ClC1=CC(/C=C/C(N[C@H](C(NC2=CC=C(C=C2)C(O)=O)=O)CC(N3CCN(CC3)C4=CC=CC=C4)=O)=O)=C(C=C1)N5C=NN=N5
  • Molecular Weight: 629.07
  • References & Citations: [1]Yao N, et al. Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors. J Med Chem. 2022; 65(5):4318-4334.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported