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FXIa-IN-9

CAT:
804-HY-150682
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
FXIa-IN-9 - image 1

FXIa-IN-9

  • CAS Number: 2816108-87-7
  • UNSPSC Description: FXIa-IN-9 (compound 3f) is a potent and selective FXIa inhibitor. FXIa-IN-9 can bind with FXIa and form hydrogen bond (human FXIa Ki: 0.17 nM, rabbit FXIa Ki: 0.5 nM). FXIa-IN-9 also has anticoagulant activity, and can be used in the research of thromboembolic diseases such as atrial fibrillation, stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism[1].
  • Target Antigen: Factor Xa
  • Type: Reference compound
  • Related Pathways: Metabolic Enzyme/Protease
  • Applications: Neuroscience-Neuromodulation
  • Field of Research: Cardiovascular Disease
  • Assay Protocol: https://www.medchemexpress.com/fxia-in-9.html
  • Solubility: 10 mM in DMSO
  • Smiles: CN1N=NC=C1C2=CN(N=C2)C(CCOC(F)F)C3=CC=C(C=[N+]3[O-])C4=C(C=CC(Cl)=C4F)N5N=NC(Cl)=C5
  • Molecular Weight: 580.35
  • References & Citations: [1]Guozhang Xu, et al. Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. J Med Chem. 2022 Jul 21.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported