FXIa-IN-10
CAT:
804-HY-151196
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
FXIa-IN-10
- CAS Number: 2816108-08-2
- UNSPSC Description: FXIa-IN-10 (Compound 3f) is a potent activated factor XI (FXIa) inhibitor with an Ki of 0.17 nM. FXIa-IN-10 has good oral bioavailability[1].
- Target Antigen: Others
- Type: Reference compound
- Related Pathways: Others
- Applications: Neuroscience-Neuromodulation
- Field of Research: Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/fxia-in-10.html
- Solubility: 10 mM in DMSO
- Smiles: CN1N=NC=C1C2=CN([C@@H](C3=CC=C(C4=C(N5N=NC(Cl)=C5)C=CC(Cl)=C4F)C=[N+]3[O-])CCOC(F)F)N=C2
- Molecular Weight: 580.35
- References & Citations: [1]Xu G, et al. Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. J Med Chem. 2022 Aug 11;65(15):10419-10440.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported