FXIa-IN-15

FXIa-IN-15

• CAS Number: 3053222-76-4
• UNSPSC Description: FXIa-IN-15 (Compound (S)-10h) is an inhibitor for Factor XIa (FXIa) and plasma kallikrein (PKa) with an IC50 of 0.38 nM and 59.2 nM. FXIa-IN-15 exhibits anticoagulant efficacy, that extends 50% activated partial thromboplastin time (aPTT) with EC1.5X of 0.55 μM[1].
• Target Antigen: Kallikrein
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/fxia-in-15.html
• Smiles: COC1=CN(C(C=C1C2=CC(Cl)=CC=C2N3C=C(N=N3)C(F)(F)F)=O)[C@H](C4=CN(N=N4)C5=CC=C(C=C5)C(O)=O)CC6=CC=CC=C6
• Molecular Weight: 662.02
• References & Citations: [1]Dai L, et al., Discovery of potent and selective factor XIa inhibitors incorporating triazole-based benzoic acid as novel P2' fragments: Molecular dynamics simulations and anticoagulant activity. Eur J Med Chem. 2025 Jan 15;282:117067.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported