FXIa-IN-6

FXIa-IN-6

• CAS Number: 1551459-37-0
• UNSPSC Description: FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases (Ki = 0.3 nM).
• Target Antigen: Factor Xa
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/fxia-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: COC(NC1=CC=C(C2=CC=NC([C@](N3C(C=C(C4=C(C(Cl)=CC=C4F)F)CC3)=O)([H])CCC[C@H](C(N5)=O)C)=C2)C5=C1)=O
• Molecular Weight: 595.04
• References & Citations: [1]Yang W, et al. Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species. J Med Chem. 2020 Jul 9;63(13):7226-7242.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported