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FXIa-IN-6

CAT:
804-HY-145349
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
FXIa-IN-6 - image 1

FXIa-IN-6

  • CAS Number: 1551459-37-0
  • UNSPSC Description: FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases (Ki = 0.3 nM).
  • Target Antigen: Factor Xa
  • Type: Reference compound
  • Related Pathways: Metabolic Enzyme/Protease
  • Applications: Neuroscience-Neuromodulation
  • Field of Research: Cardiovascular Disease
  • Assay Protocol: https://www.medchemexpress.com/fxia-in-6.html
  • Solubility: 10 mM in DMSO
  • Smiles: COC(NC1=CC=C(C2=CC=NC([C@](N3C(C=C(C4=C(C(Cl)=CC=C4F)F)CC3)=O)([H])CCC[C@H](C(N5)=O)C)=C2)C5=C1)=O
  • Molecular Weight: 595.04
  • References & Citations: [1]Yang W, et al. Discovery of a High Affinity, Orally Bioavailable Macrocyclic FXIa Inhibitor with Antithrombotic Activity in Preclinical Species. J Med Chem. 2020 Jul 9;63(13):7226-7242.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported