FXIa-IN-9

• Target:

  Others|||Factor Xa

• Related Pathways:

  Metabolism|||Others

• Bioactivity:

  FXIa-IN-9 (compound 3f) is a potent, selective inhibitor of FXIa, demonstrating strong binding affinity through hydrogen bond formation (human FXIa Ki: 0.17 nM, rabbit FXIa Ki: 0.5 nM) . It exhibits anticoagulant properties, making it valuable for research into thromboembolic conditions, including atrial fibrillation, stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism [1].

• Smiles:

  FC=1C(=C(C=CC1Cl)N2N=NC(Cl)=C2)C3=CN(=O)=C(C(CCOC(F)F)N4C=C(C=N4)C=5N(C)N=NC5)C=C3

• Molecular Formula:

  C23H18Cl2F3N9O2

• Molecular Weight:

  580.35

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2816108-87-7