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STING agonist-11

CAT: 0804-HY-144329Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144329Size:1 Each
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Description
STING agonist-11 (Compound 92) is a potent small molecule cyclic urea activator of STING with EC50 of 18 nM. Activation of STING is a highly promising approach in immunotherapy[1].
CAS Number
2259308-68-2
UNSPSC
12352005
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/sting-agonist-11.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C(C=C1)[C@H](C)N(C)C(N2CC3=C(F)C=CC=C3Cl)=O)NCC4=C(F)C=C(F)C=C4F
Molecular Formula
C25H20ClF4N3O2
Molecular Weight
505.89
References & Citations
[1]Sourav Basu, et al. The discovery of potent small molecule cyclic urea activators of STING. Eur J Med Chem. 2022 Feb 5;229:114087.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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