STING agonist-48

• Description :

  STING agonist-48 is a potent STING agonist that exhibits STING-dependent activity in vitro (EC50 = 4.02 μM) . STING agonist-48 prefers to bind with the transmembrane domain (TMD) over the cytosolic cyclic dinucleotide (CDN) domain. STING agonist-48 shows adjuvant efficacy, enhancing IgG and Th1/Th2 cytokine responses in humanized STING mice. STING agonist-48 can be used for the study of inflammation-related diseases[1].

• Target :

  STING

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Infection; Inflammation/Immunology

• Smiles :

  O=C(C1=CC=C(N2CC3=C(O)C=CC=C3F)C(SCC2=O)=C1)NCC4=C(F)C=C(F)C=C4F

• Molecular Formula :

  C23H16F4N2O3S

• Molecular Weight :

  476.44

• References & Citations :

  [1]Junaid A, et al. In silico discovery and mechanistic profiling of STING agonists engaging the transmembrane domain. Eur J Med Chem. 2026 Jan 5;301:118201.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3027712-31-5]