STING agonist-23

• Description:

  STING agonist-23 (CF502) is a non-nucleotide small-molecule STING agonist. STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3. STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells. STING agonist-23 exhibits activity against SARS-CoV series strains[1].

• UNSPSC:

  12352005

• Target:

  STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sting-agonist-23.html

• Purity:

  99.33

• Solubility:

  DMSO : 3.12 mg/mL (ultrasonic; warming; adjust pH to 3 with HCl; heat to 60°C)

• Smiles:

  CCN1N=C(C=C1C(NC2=NC3=C(N2C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4N=CC(C(N)=O)=C6)C=CC(C(N)=O)=C3)=O)C

• Molecular Formula:

  C33H35N13O4

• Molecular Weight:

  677.72

• References & Citations:

  [1]Liu Z, et al. A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs. Cell Res. 2022 Mar;32 (3) :269-287.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2361570-16-1]