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STING agonist-45

CAT: 0804-HY-177338Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-177338Size:1 Each
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Description
STING agonist-45 is a selective STING agonist (EC50 = 0.28 μM) . STING agonist-45 activates the innate immune response through the cGAS-STING pathway, upregulating key markers such as p-TBK1 and IRF3. STING agonist-45 exhibits robust STING activation in human peripheral blood mononuclear cells (PBMCs), inducing the production of type I interferons (such as IFN-β) and downstream cytokines (such as TNF-α and IL-6) . STING agonist-45 enhances anti-tumor immunity, inhibits tumor growth, and increases CD8+ T cell infiltration in mouse models. STING agonist-45 is promising for the study of STING-related diseases[1][2].
CAS Number
[2361424-97-5]
UNSPSC
12352005
Target
Cyclic GMP-AMP Synthase; IFNAR; Interleukin Related; STING; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=CC2=C(C(OC3COC3)=C1)N(CCC)C(NC(C4=CC(C)=NN4CC)=O)=N2)N
Molecular Formula
C21H26N6O4
Molecular Weight
426.47
References & Citations
[1]Shan B, et al. Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. J Med Chem. 2023 Mar 9;66 (5) :3327-3347.|[2]Jin Li, et al. Immunomodulator, WO2019134707A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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