STING Agonist D61

• Target:

  Others|||STING

• Related Pathways:

  Others|||Immunology/Inflammation

• Bioactivity:

  STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-?-inducible reporter genes in cellular assays, with half-maximal effective concentrations (EC50s) of 52.9 and 116 nM, respectively. At concentrations of 4, 6, and 8 µM, D61 enhances the production of IFN-? and chemokine (C-X-C motif) ligand 10 (CXCL10) mRNA, as well as the phosphorylation of TANK-binding kinase 1 (TBK1), IRF3, and STING in THP-1 monocytes. Additionally, when administered at a dose of 0.25 mg/kg every other day, D61 effectively reduces tumor volume in a CT26 murine colon cancer model without impacting the body weight of the subjects.

• Smiles:

  COC1=C2C (N=C (NC (C3=CC (C) =NN3CC) =O) N2CCCNC4=NC=C (C5=C (C (F) (F) F) C=CC=C5) O4) =CC (C (N) =O) =C1

• Molecular Formula:

  C29H29F3N8O4

• Molecular Weight:

  610.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2850251-27-1