STING Agonist D61

CAT: 0931-T83841-01Size: 500 µgDry Ice: NoHazardous: No

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CAT#:0931-T83841-01Size:500 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2850251-27-1

Target

Others, STING

Related Pathways

Others, Immunology/Inflammation

Bioactivity

STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular assays, with half-maximal effective concentrations (EC50s) of 52.9 and 116 nM, respectively. At concentrations of 4, 6, and 8 μM, D61 enhances the production of IFN-β and chemokine (C-X-C motif) ligand 10 (CXCL10) mRNA, as well as the phosphorylation of TANK-binding kinase 1 (TBK1), IRF3, and STING in THP-1 monocytes. Additionally, when administered at a dose of 0.25 mg/kg every other day, D61 effectively reduces tumor volume in a CT26 murine colon cancer model without impacting the body weight of the subjects.

Smiles

COC1=C2C(N=C(NC(C3=CC(C)=NN3CC)=O)N2CCCNC4=NC=C(C5=C(C(F)(F)F)C=CC=C5)O4)=CC(C(N)=O)=C1

Molecular Formula

C29H29F3N8O4

Molecular Weight

610.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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