STING agonist-44

• Description :

  STING agonist-44 (Compound 4) is a potent and selective STING agonist with an EC50 value of 5.68 for IRF induction in THP1 cells and 2.212 μM in RAW cells. STING agonist-44 activates the STING pathway, inducing the production of type I interferons and pro-inflammatory cytokines (e.g., CXCL10, TNFα) . STING agonist-44 is promising for research of cancers[1].

• UNSPSC :

  12352005

• Target :

  STING

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O[C@H]1[C@@H](OP(SC[C@]23[C@@H](O4)[C@@H](OC3)[C@H](N5C=NC6=C5N=CN=C6N)O2)(O)=O)[C@H](N(C=N7)C8=C7C(NC(N)=N8)=O)O[C@@H]1COP4(O)=O

• Molecular Formula :

  C21H24N10O12P2S

• Molecular Weight :

  702.49

• References & Citations :

  [1]Yeboah S K, et al. 5′-Phosphorothioester Linked Cyclic Dinucleotides, Endo-S-CDNs, Displaying Impressive Antitumor Activities In Vivo when Dosed Subcutaneously[J]. ACS Bio & Med Chem Au, 2025.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported