Products for Research Use Only
RegisterLogin

MRS 1523 (Standard)

CAT: 0804-HY-121119RSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-121119RSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MRS 1523 (Standard) is the analytical standard of MRS 1523. This product is intended for research and analytical applications. MRS 1523 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons[1][2].
CAS Number
212329-37-8
UNSPSC
12352100
Target
Adenosine Receptor; Calcium Channel; Reference Standards
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
O=C(OCCC)C1=C(C(C(SCC)=O)=C(N=C1C2=CC=CC=C2)CC)CCC
Molecular Formula
C23H29NO3S
Molecular Weight
399.55
References & Citations
[1]Li AH, et al. Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.J Med Chem. 1998 Aug 13;41 (17) :3186-201.|[2]Coppi E, et al. Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.Pain. 2019 May;160 (5) :1103-1118.|[3]Fernandez P, et al. Adenosine A₂A and A₃ receptors are involved in the human endothelial progenitor cells migration. J Cardiovasc Pharmacol. 2012 May;59 (5) :397-404.|[4]Yoshikawa N, et al. Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377 (4-6) :591-5.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Related Products

CatalogName
HY-121119-01MRS 1523
HY-14121R-01MRS 1754 (Standard)
HY-13104RMRS 2578 (Standard)
HY-124543R-01MRS-1191 (Standard)
HY-103186R-01MRS-1706 (Standard)
HY-139745AFPI-1523
HY-129301CCTA-1523
HY-115273MRS-2179
HY-145654MRS-4203
HY-13104-01MRS 2578

Alternative Products

CatalogName
T16135-01MRS 1523
T38940FPI-1523
MBS3617301-01CCTA-1523
T38941-01FPI-1523 sodium
33-721NKX2.2 Antibody [NX2/1523]
BM300098MRS 1523 - Bio-X TM
217156Adenosine A3 Receptor Antagonist, MRS 1523 (3-propyl-6-ethyl-5[ (ethylthio) carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate, MRS 1523, MRS-1523)
NBP2-53200-100ugMouse Monoclonal NKX2.2 Antibody (NX2/1523)
NBP3-07409-20ugMouse Monoclonal NKX2.2 Antibody (rNX2/1523)

Popular Products