INU-152

• UNSPSC Description:

  INU-152 is a potent and selective B-Raf inhibitor. INU-152 reduces tumor cell proliferation, enhances autophagy, and induces apoptosis by inhibiting B-Raf activity. INU-152 exhibits significant cytotoxicity against cancer cells transformed with v-Ha-ras (Ras-NIH 3T3). INU-152 can be utilized in cancer research[1].

• Target Antigen:

  Apoptosis; Autophagy; Raf

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/inu-152.html

• Smiles:

  FC(C=CC(NS(=O)(C1=COC=C1)=O)=C2F)=C2NC3=NC=CC=C3C4=NC=NC5=C4N=CN5

• Molecular Weight:

  469.42

• References & Citations:

  [1]Ahn JH, et al. The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts. Biochem Biophys Res Commun. 2012 Jan 13;417(2):857-63.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1380228-30-7