INU-152

• Description :

  INU-152 is a potent and selective B-Raf inhibitor. INU-152 reduces tumor cell proliferation, enhances autophagy, and induces apoptosis by inhibiting B-Raf activity. INU-152 exhibits significant cytotoxicity against cancer cells transformed with v-Ha-ras (Ras-NIH 3T3) . INU-152 can be utilized in cancer research[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Apoptosis; Autophagy; Raf

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy; MAPK/ERK Pathway

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/inu-152.html

• Smiles :

  FC(C=CC(NS(=O)(C1=COC=C1)=O)=C2F)=C2NC3=NC=CC=C3C4=NC=NC5=C4N=CN5

• Molecular Formula :

  C20H13F2N7O3S

• Molecular Weight :

  469.42

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

• References & Citations :

  [1]Ahn JH, et al. The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts. Biochem Biophys Res Commun. 2012 Jan 13;417 (2) :857-63.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1380228-30-7]