FPI-1465

FPI-1465

• CAS Number: 1452458-70-6
• UNSPSC Description: FPI-1465 acts a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs).FPI-1465 inhibits PBP2 (IC50=1.0 µg/mL). FPI-1465 exhibits activity against β-lactamase CTX-M-15 and OXA-48 with Kds of 0.011 and 5.3 µM, respectively[1].
• Target Antigen: Bacterial; Beta-lactamase; Penicillin-binding protein (PBP)
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/fpi-1465.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H]1[N@@]2C(N([C@H](CC1)C2)OS(=O)(O)=O)=O)NO[C@@H]3CCNC3
• Molecular Weight: 350.35
• References & Citations: [1]Andrew M King, et al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported