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BMS-687453

CAT: 0804-HY-10678-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10678-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-687453 is a potent and selective PPARα agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.
CAS Number
1000998-59-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/BMS-687453.html
Purity
99.31
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC(C=C1)=CC=C1C2=NC(COC3=CC=CC(CN(C(OC)=O)CC(O)=O)=C3)=C(C)O2
Molecular Formula
C22H21ClN2O6
Molecular Weight
444.86
Precautions
H302, H315, H319, H335
References & Citations
[1]Li J, et al. Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2- ((3- ((2- (4-chlorophenyl) -5-methyloxazol-4-yl) methoxy) benzyl) (methoxycarbonyl) amino) acetic acid (BMS-687453) . J Med Chem. 2010 Apr 8;53 (7) :2854-64.|[2]Mukherjee R, et al. Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist. J Pharmacol Exp Ther. 2008 Dec;327 (3) :716-26.|[3]Vassallo JD, et al. Biomarkers of drug-induced skeletal muscle injury in the rat: troponin I and myoglobin. Toxicol Sci. 2009 Oct;111 (2) :402-12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα

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Alternative Products

CatalogName
S0170-01BMS-687453
C3544-25BMS 687453
A15836-50BMS-687453 50mg
A15836-1BMS-687453 1mg
A15836-25BMS-687453 25mg
A15836-10BMS-687453 10mg
A15836-100BMS-687453 100mg
A15836-5BMS-687453 5mg
A15836-2BMS-687453 2mg
A15836-10mM-DBMS-687453 10mM * 1mL in DMSO

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