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EZH2-IN-1

CAT: 0804-HY-122595Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122595Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EZH2-IN-1 (compound 3) is a selective and SAM-competitive EZH2 and EZH1 inhibitor with an IC50s of 32 nM, 197 nM and 213 nM for EZH2wt, EZH2 Y641N mutant and EZH1, respectively. EZH2-IN-1 reduces bulk H3K27me3 and H3K27me2 levels. EZH2-IN-1 has the potential for diffuse large B cell lymphoma research[1].
CAS Number
1377997-28-8
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ezh2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CC(C)(C)NC(C)(C)C1)C2=CC=C(OC3=CC=CC(C4=CC=NN=C4)=C3C#N)C(Cl)=C2
Molecular Formula
C27H28ClN5O2
Molecular Weight
490.00
References & Citations
[1]Shivani Garapaty-Rao, et al.Identification of EZH2 and EZH1 small molecule inhibitors with selective impact on diffuse large B cell lymphoma cell growth. Chem Biol. 2013 Nov 21;20 (11) :1329-39.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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