EZH2-IN-23

• Description:

  EZH2-IN-23 (Compound 25) is an EZH2 inhibitor that exhibits potent enzymatic inhibition of the PRC2 complex (EZH2, EED, SUZ12, AEBP2, RbAp48) with a biochemical IC50 of 0.8 nM. EZH2-IN-23 inhibits H3K27 trimethylation in cellular assays, showing an IC50 of 40 nM. EZH2-IN-23 displays good rat PKproperties with 100 % oral bioavailability[1].

• UNSPSC:

  12352100

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  CC(N1)=CC(C)=C(CN2CCC(SC([C@H](C)C3CCN(CC4=NC=C(Cl)C=C4)CC3)=C5C)=C5C2=O)C1=O

• Molecular Formula:

  C29H35ClN4O2S

• Molecular Weight:

  539.13

• References & Citations:

  [1]Tian X, et, al. Asymmetric synthesis of potent and orally bioavailable thiophene-based EZH2 inhibitors. Bioorg Med Chem Lett. 2025 May 30;127:130291.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3095068-20-2]