EZH2-IN-4

EZH2-IN-4

• CAS Number: 2088132-99-2
• UNSPSC Description: EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity[1].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ezh2-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C([C@@H]([C@@]2([H])CC[C@@](N3CC(C3)OC)([H])CC2)C)SC(CCCN4CC5=C(C=C(NC5=O)C)C)=C1C4=O
• Molecular Weight: 511.72
• References & Citations: [1]Esteban DOMINGUEZ, et al. Inhibitors of ezh2. WO2017035060A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported