EZH2-IN-4

CAT:
804-HY-139150
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
EZH2-IN-4 - image 1

EZH2-IN-4

  • UNSPSC Description:

    EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity[1].
  • Target Antigen:

    Histone Methyltransferase
  • Type:

    Reference compound
  • Related Pathways:

    Epigenetics
  • Applications:

    Cancer-programmed cell death
  • Field of Research:

    Cancer
  • Assay Protocol:

    https://www.medchemexpress.com/ezh2-in-4.html
  • Solubility:

    10 mM in DMSO
  • Smiles:

    CC1=C([C@@H]([C@@]2([H])CC[C@@](N3CC(C3)OC)([H])CC2)C)SC(CCCN4CC5=C(C=C(NC5=O)C)C)=C1C4=O
  • Molecular Weight:

    511.72
  • References & Citations:

    [1]Esteban DOMINGUEZ, et al. Inhibitors of ezh2. WO2017035060A1.
  • Shipping Conditions:

    Room temperature
  • Clinical Information:

    No Development Reported
  • CAS Number:

    2088132-99-2