EZH2-IN-2

• Description:

  EZH2-IN-2 (Example 69) is a EZH2 inhibitor with an IC50 and a TR-FRET IC50 of 64 nM and 20 nM. EZH2-IN-2 can be used for the research of cancer or precancerous condition related to EZH2 activity[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ezh2-in-2.html

• Purity:

  99.60

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (NCC1=C (C) C=C (C) NC1=O) C2=CC (C3=CC=C (N4CCN (CC5CC5) CC4) N=C3C) =CC (N (C (C6CC6) =O) CC) =C2C

• Molecular Formula:

  C36H46N6O3

• Molecular Weight:

  610.79

• References & Citations:

  [1]LIU, Qing Song, et al. Ezh2 inhibitor and use thereof. WO2018133795A1.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EZH2

• CAS Number:

  2238821-31-1