EZH2-IN-18

• UNSPSC Description:

  EZH2-IN-18 (compound 9e) is a potent inhibitor of enhancer of zeste homologue 2 (EZH2WT) , with the IC50 of 1.01 nM. EZH2-IN-18 shows inhibition in proliferation and induction in apoptosis in tumor cells[1].

• Target Antigen:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ezh2-in-18.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C(CNC(C2=CC(C3=CC=C(Br)C=C3)=CC(N4)=C2C=CC4=O)=O)=C(C)C=C(C)N1

• Molecular Weight:

  478.34

• References & Citations:

  [1]Jin Cai, et al. Design, synthesis and activity evaluation of quinolinone derivatives as EZH2 inhibitors. Bioorg Med Chem Lett. 2024 Jun 1:105:129726.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2826234-37-9