EZH2-IN-18

EZH2-IN-18

• CAS Number: 2826234-37-9
• UNSPSC Description: EZH2-IN-18 (compound 9e) is a potent inhibitor of enhancer of zeste homologue 2 (EZH2WT) , with the IC50 of 1.01 nM. EZH2-IN-18 shows inhibition in proliferation and induction in apoptosis in tumor cells[1].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ezh2-in-18.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(CNC(C2=CC(C3=CC=C(Br)C=C3)=CC(N4)=C2C=CC4=O)=O)=C(C)C=C(C)N1
• Molecular Weight: 478.34
• References & Citations: [1]Jin Cai, et al. Design, synthesis and activity evaluation of quinolinone derivatives as EZH2 inhibitors. Bioorg Med Chem Lett. 2024 Jun 1:105:129726.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported