PDE4-IN-6

PDE4-IN-6

• UNSPSC Description: PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC50s of 0.125 and 0.43 μM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde4-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: CC(CCC1=C(OC(C2=CC(F)=CC=C21)=O)C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CC=C3)=O
• Molecular Weight: 465.49
• References & Citations: [1]Thirupataiah B, et al. Fe(III)-catalyzed regioselective and faster synthesis of isocoumarins with 3-oxoalkyl moiety at C-4: Identification of new inhibitors of PDE4. Bioorg Chem. 2022;121:105667.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported