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BMS-536924

CAT: 0804-HY-10262-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10262-01Size:1 mg
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Description
BMS-536924 is an orally active, competitive and selective insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IR) inhibitor with IC50s of 100 nM and 73 nM, respectively. BMS-536924 has anti-cancer activity[1][2].
CAS Number
468740-43-4
UNSPSC
12352005
Target
Apoptosis; IGF-1R; Insulin Receptor
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/BMS-536924.html
Purity
99.83
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(C2=NC3=CC(N4CCOCC4)=CC(C)=C3N2)=C(C=CN1)NC[C@@H](O)C5=CC=CC(Cl)=C5
Molecular Formula
C25H26ClN5O3
Molecular Weight
479.96
References & Citations
[1]Wittman M, et al. Discovery of a (1H-benzoimidazol-2-yl) -1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. J Med Chem. 2005 Sep 8;48 (18) :5639-43.|[2]Litzenburger BC, et al. BMS-536924 reverses IGF-IR-induced transformation of mammary epithelial cells and causes growth inhibition and polarization of MCF7 cells. Clin Cancer Res. 2009 Jan 1;15 (1) :226-37.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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