GPX4-IN-13
CAT:
804-HY-163995
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GPX4-IN-13
- CAS Number: 2644044-43-7
- UNSPSC Description: GPX4-IN-13 (compound 16) is a GPX4 inhibitor with anticancer activity. GPX4-IN-13 reduces thyroid cell proliferation and induces ferroptosis by inhibiting the expression level of GPX4. GPX4-IN-13 inhibits the growth of three thyroid cancer cell lines: N-thy-ori-3-1 (IC50=8.39 μM), MDA-T32 (IC50=10.28 μM) and MDA-T41 (IC50=8.18 μM)[1].
- Target Antigen: Ferroptosis; Glutathione Peroxidase
- Type: Reference compound
- Related Pathways: Apoptosis;Metabolic Enzyme/Protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/gpx4-in-13.html
- Smiles: O=C(C1=CC=C(C=C1)C#N)/C=C/C(C=CC=C2)=C2OC3=C(C=CC=C3)C=O
- Molecular Weight: 353.37
- References & Citations: [1]Pamarthy, et al. "Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells." Drug Development Research 84.5 (2023): 861-887.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported