GPX4-IN-14

GPX4-IN-14

• UNSPSC Description: GPX4-IN-14 (compound 2c) is an inhibitor of GPX4, with free radical scavenging activity (maximum scavenging rate is 72.52%) and anti-tumor proliferation activity in vitro. GPX4-IN-14 inhibits GPX4 protein, increases lipid peroxide levels and intracellular Reactive Oxygen Species (ROS) levels, thereby inducing ferroptosis and exerting anti-tumor proliferation effects[1].
• Target Antigen: Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/gpx4-in-14.html
• Smiles: O=C(CCC(OCCCCCC[Se]C#N)=O)O[C@H]1[C@H](C)[C@@]2([H])[C@]3([C@]4([H])[C@H](C)CC2)[C@](O[C@@](OO3)(C)CC4)([H])O1
• Molecular Weight: 572.55
• References & Citations: [1]Meilin Ren, et al. Design, synthesis and biological evaluation of artesunate-Se derivatives as anticancer agents by inducing GPX4-mediated ferroptosis. Bioorg Chem. 2024 Nov:152:107733.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported