GPX4-IN-7
CAT:
804-HY-156286
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GPX4-IN-7
- UNSPSC Description: GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC50 value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis[1].
- Target Antigen: Ferroptosis
- Type: Reference compound
- Related Pathways: Apoptosis
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/gpx4-in-7.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(NCC1CCN(CC1)C(CCl)=O)C(C=C2C/3=O)=CC=C2NC3=C4C(C=CC=C5)=C5NC\4=O
- Molecular Weight: 478.93
- References & Citations: [1]Zhu JM, et al. Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer. Eur J Med Chem. 2023 Sep 28;261:115829.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported