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GPX4-IN-7

CAT: 0804-HY-156286Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156286Size:1 Each
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Description
GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC50 value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis[1].
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1CCN(CC1)C(CCl)=O)C(C=C2C/3=O)=CC=C2NC3=C4C(C=CC=C5)=C5NC\4=O
Molecular Formula
C25H23ClN4O4
Molecular Weight
478.93
References & Citations
[1]Zhu JM, et al. Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer. Eur J Med Chem. 2023 Sep 28;261:115829.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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