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GPX4-IN-16

CAT: 0804-HY-168879Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168879Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPX4-IN-16 ((R) -9i) is a potent GPX4 inhibitor with an Kd value of 20.4 nM. GPX4-IN-16 shows cytotoxicity. GPX4-IN-16 shows anticancer activity[1].
UNSPSC
12352005
Target
Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CSC(C#C)=N1)N([C@H](C2=CSC3=CC=CC=C32)C(NC(C)(C)C)=O)C4=CC=C(C5=CN=CO5)C=C4
Molecular Formula
C29H24N4O3S2
Molecular Weight
540.66
References & Citations
[1]Gu S, et al. Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2-Ethynylthiazole-4-carboxamide as Electrophilic Warhead. J Med Chem. 2025 Jan 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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