GPX4-IN-9

GPX4-IN-9

• CAS Number: 3032746-99-6
• UNSPSC Description: GPX4-IN-9 (Compound A16) is a glutathione peroxidase 4 (GPX4) inhibitor that specifically targets GPX4 under both in vitro and in vivo conditions, inducing ferroptosis. GPX4-IN-9 exhibits cytotoxicity against pancreatic cancer cells and can be used in cancer research[1].
• Target Antigen: Ferroptosis; Glutathione Peroxidase
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/gpx4-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(C(C=C1)=CC=C1CN(C2=CC=C(C=C2)C3=NC4=C(S3)C=CC=C4)CC#C)(N(C#C)C)=O
• Molecular Weight: 471.59
• References & Citations: [1]Tang Z, et al. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in PancrTang Z, et al. Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy. J Med Chem. 2024 Feb 8;67(3):1872-1887.eatic Cancer Therapy. J Med Chem. 2024 Feb 8;67(3):1872-1887.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported