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GPX4-IN-13

CAT: 0931-T200339-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200339-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2644044-43-7
Target
Glutathione Peroxidase, Ferroptosis
Related Pathways
Metabolism, Apoptosis
Bioactivity
GPX4-IN-13 (compound 16), a GPX4 inhibitor, exhibits anticancer properties by diminishing the expression of GPX4, thereby reducing thyroid cell proliferation and inducing ferroptosis. Additionally, this compound effectively inhibits the growth of three distinct thyroid cancer cell lines: N-thy-ori-3-1 (IC 50 =8.39 μM), MDA-T32 (IC 50 =10.28 μM), and MDA-T41 (IC 50 =8.18 μM) .
Smiles
O(C1=C(/C=C/C(=O)C2=CC=C(C#N)C=C2)C=CC=C1)C3=C(C=O)C=CC=C3
Molecular Formula
C23H15NO3
Molecular Weight
353.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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