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GPX4-IN-18

CAT: 0804-HY-175041Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175041Size:1 Each
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Description
GPX4-IN-18 (Compound 17) is a ferrocene-containing inhibitor of glutathione peroxidase 4 (GPX4) . GPX4-IN-18 is also an inducer of ferroptosis. GPX4-IN-18 can increase the production of ROS and malondialdehyde (MDA) levels in OS-RC-2 clear cell renal cell carcinoma cells. GPX4-IN-18 induces ferroptosis in HT-1080 cells with IC50s of 0.007 μM (absence of ferrostatin-1) and 1.486 μM (presence of ferrostatin-1) . GPX4-IN-18 reduces in vivo tumor volume and intratumoral GPX4 levels in OS-RC-2 xenograft murine model[1].
CAS Number
3016433-00-1
UNSPSC
12352005
Target
Cannabinoid Receptor; Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C#C)N(C(c1cccc1)C(N(CCC2=CC=CC=C2)[H])=O)C3=CC(Cl)=C(OC)C=C3.[][Fe][].c4cccc4
Molecular Formula
C30H27ClFeN2O3
Molecular Weight
554.84
References & Citations
[1]Li, W., et al., (2024) . How does ferrocene correlate with ferroptosis? Multiple approaches to explore ferrocene-appended GPX4 inhibitors as anticancer agents. Chemical science, 15 (27), 10477–10490.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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