YX-02-030

CAT: 0804-HY-158684-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-158684-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

YX-02-030M is a PROTAC MDM2 degrader. YX-02-030M inhibits MDM2-p53 binding and VHL-HIF1α binding with IC50s of 63 nM and 1.35 μM respectively. YX-02-030M binds MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, and effectively kills p53 mutant or deleted Triple-negative breast cancers (TNBC) cells[1].

CAS Number

3049076-98-1

UNSPSC

12352005

Target

MDM-2/p53; PROTACs

Type

Reference compound

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/yx-02-030.html

Purity

99.86

Smiles

O=C(CN1CCN(C(N2[C@](C)(C3=CC=C(Cl)C=C3)[C@](C)(C4=CC=C(Cl)C=C4)N=C2C5=CC=C(C(C)(C)C)C=C5OCC)=O)CC1)NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](O)C6)=O)=O

Molecular Formula

C66H85Cl2N9O10S

Molecular Weight

1267.41

References & Citations

[1]Adams CM, et al. Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer. Cancer Discov. 2023 May 4;13 (5) :1210-1229.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T208219-01	YX-02-030
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T84478-01	JWH 030
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452935-01	JWH-030
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