TP-030-2

CAT: 0804-HY-148239-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148239-01Size:5 mg
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Description
TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM) [1][2].
CAS Number
[2095514-84-2]
UNSPSC
12352005
Target
RIP kinase; Ser/Thr Protease
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-030-2.html
Purity
98.32
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=NN(CC3=CC=CC=C3)C(Br)=C2CCN1[C@@H]4C(N(C5=CC=CC=C5OC4)C)=O
Molecular Formula
C23H21BrN4O3
Molecular Weight
481.34
References & Citations
[1]Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61 (6) :2384-2409.|[2]https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-2
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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