TP-030-2

• Description :

  TP-030-2, a chemical probe, is a RIPK1 inhibitor (human Ki=0.43 nM; mouse IC50=100 nM) [1][2].

• UNSPSC :

  12352005

• Target :

  RIP kinase; Ser/Thr Protease

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tp-030-2.html

• Purity :

  98.32

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C2=NN(CC3=CC=CC=C3)C(Br)=C2CCN1[C@@H]4C(N(C5=CC=CC=C5OC4)C)=O

• Molecular Formula :

  C23H21BrN4O3

• Molecular Weight :

  481.34

• References & Citations :

  [1]Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61 (6) :2384-2409.|[2]https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-2

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2095514-84-2]