YX-02-030

CAT: 0931-T208219-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T208219-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3049076-98-1

Target

MDM-2/p53, PROTACs

Related Pathways

Apoptosis, PROTAC

Bioactivity

YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1α, with IC50 values of 63 nM and 1.35 μM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.

Smiles

C[C@@]1(N(C(=O)N2CCN(CC(NCCOCCOCCOCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)[C@@](C)(C)C)=O)=O)CC2)C(=N[C@@]1(C)C6=CC=C(Cl)C=C6)C7=C(OCC)C=C(C(C)(C)C)C=C7)C8=CC=C(Cl)C=C8

Molecular Formula

C66H85Cl2N9O10S

Molecular Weight

1267.41

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

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GTR19261252-01	YX-02-030
HY-158684A-01	(4R,5S) -YX-02-030
BA3798-5	YX-2-107
MBS5758230	ML-030
MBS5812060	CLE-030
HY-P990670-01	TTX-030
452935-01	JWH-030
MBS5813955	LM-030

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