NJH-2-030

CAT: 0804-HY-143348-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-143348-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NJH-2-030 can be used as a covalent recruiter for FEM1B in targeted protein degradation applications. NJH-2-030 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CAS Number

2709040-02-6

UNSPSC

12352005

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/njh-2-030.html

Purity

98.74

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C#CCCCC(N1CCOC2=C1C=CC(N(C(CCl)=O)CCC#N)=C2)=O

Molecular Formula

C19H20ClN3O3

Molecular Weight

373.83

References & Citations

[1]Henning NJ, et al. Discovery of a Covalent FEM1B Recruiter for Targeted Protein Degradation Applications. J Am Chem Soc. 2022 Jan 19;144 (2) :701-708.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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Alternative Products

Catalog	Name
T61521-01	NJH-2-030
BA6618-10	NJH-2-057
BA6625-1	NJH-2-056
GTR19213217	NJH-2-075
BA3514-10	TP-030-2
T5496-01	ML-030
T84478-01	JWH 030
MBS5812060	CLE-030

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