RegisterLogin

TP-030-1

CAT: 0804-HY-148253Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-148253Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
TP-030-1, a chemical probe, is an inhibitor of RIPK1. TP-030-1 inhibits hRIPK1 with a Ki value of 3.9 nM and inhibits mRIPK1 with an IC50 value of 4.2 μM. TP-030-1 can be used for the research of inflammatory diseases and neurodegenerative diseases[1].
CAS Number
[2095514-75-1]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tp-030-1.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@H](N2CCC3=CN(CC4=CC=CC=C4)N=C3C2=O)COC5=CC=CC=C5N1C
Molecular Formula
C23H22N4O3
Molecular Weight
402.45
References & Citations
[1]Msato Yoshikawa, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure–Kinetic Relationships. J. Med. Chem. 2018, 61, 6, 2384–2409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-148239-01TP-030-2
HY-103050-01ML-030
HY-P990670-01TTX-030
HY-P4669LM-030
HY-160615TP receptor antagonist-1
HY-158684-01YX-02-030
HY-143348-01NJH-2-030
HY-119127TP-680
HY-114224TP-271
HY-138561EFdA-TP

Alternative Products

CatalogName
MBS5815524TP-030-1
BA3514-10TP-030-2
E51A12355TP-1 Antibody
T5496-01ML-030
T84478-01JWH 030
MBS5812060CLE-030
452935-01JWH-030
MBS5813955LM-030

Popular Products